尽管现代放化疗仍然是很难可靠的预测恶性神经胶质瘤。神经胶质瘤手术切除仍是治疗的首选方法。神经外科医生已经开发出一种新程序来分析放射成像扫描,可以相对准确的预测疾病的发展。他们的研究结果发表在《ScientificReports》杂志上。

Newclassificationsystemforbraintumours
Friedlein分级A/B(FGA/B)分类系统——是以KatharinaFriedlein医生命名的,对于既得肿瘤来说手术切除是否是最好的治疗方法?这种分类系统是一种快速和精确的鉴别方式。从本质上讲,医生对肿瘤的分类是通过常规磁共振成像(MRI)扫描肿瘤在大脑中所处的位置而得出的分类结果。肿瘤不处于大脑功能区域,或是位于与大脑功能区域有一定距离的位置被分类为大脑FGA,当肿瘤接近或在大脑功能区域时被分类为FGB。
FGA/B分类方法可能对肿瘤手术的后果有指导性,精确的、低风险和定量的方式对治疗的成功几率来说是至关重要的。这使得Friedlein分级系统可以比较容易地应用于临床实践中。目前在医学方面已经有多次实践来发展这样一个分类系统。然而,实践中大多数的方法过于复杂并且只是基于理论基础,所以使其难以在临床实践中使用它们,神经外科医生NicolaiSavaskan说,FGA/B方法尽管非常简单,但是它可以在应用标准MRI扫描基础上使神经胶质瘤患者所接受,是高度可靠的。我们希望我们的同事在小医院神经外科也能够在日常临床实践中成功地使用它。NA集群的出现和消失,包括那些不能被转基因的物种。我们的下一个目标是调查活体、单个细胞中不同的RNA的活性,什么调节RNA活性,比较健康组织和不健康组织与阐明基因表达机制和异常RNA活动引起的疾病。
原始出处
KatharinaFriedlein,YavorBozhkov,NirjharHore,AndreasMerkel,Bj?rnSommer,SebastianBrandner,MichaelBuchfelder,NicolaiE.Savaskan&IlkerY.Eyüpoglu.Anewfunctionalclassificationsystem(FGA/B)withprognosticvalueforgliomapatients.ScientificReports,July2015
Althoughmodernradiotherapyandchemotherapyarestilldifficulttoreliablypredictmalignantglioma.Surgicalresectionofgliomaisstillthefirstchoiceoftreatment.Neurosurgeonshavedevelopedanewprogramtoanalyzeimagingscans,whichcanpredictdiseasedevelopmentrelativelyaccurately.Theirfindingsarepublishedinthejournalscientificreports.
Newclassificationsystemforbraintumours
FriedleinclassificationA/b(FGA/b)systemnamedafterDr.Katharinafriedlein,issurgicalresectionthebesttreatmentforexistingtumors?Thisclassificationsystemisafastandaccuratewayofidentification.Inessence,doctors&39;classificationoftumorsistheresultofconventionalmagneticresonanceimaging(MRI)scanningthelocationoftumorsinthebrain.Tumorisnotlocatedinthefunctionalareaofthebrain,orislocatedatacertaindistancefromthefunctionalareaofthebrainisclassifiedasbrainFGA,whenthetumorisclosetoorinthefunctionalareaofthebrainisclassifiedasFGB.
FGA/bclassificationmaybehelpfulfortheoutcomeoftumorsurgery.Accurate,lowriskandquantitativemethodsareessentialforthesuccessrateoftreatment.Thismakesfriedleingradingsystemeasytoapplyinclinicalpractice.Atpresent,therehavebeenmanypracticesinmedicinetodevelopsuchaclassificationsystem.However,mostofthemethodsinpracticearetoocomplexandonlybasedontheoreticalbasis,soitisdifficulttousetheminclinicalpractice.NeurosurgeonNicolaisavaskansaidthatFGA/Bmethod,althoughverysimple,canbeacceptedbygliomapatientsonthebasisofstandardMRIscanning,whichishighlyreliable.Wehopethatourcolleaguescanalsouseitsuccessfullyinsmallhospitalneurosurgeryindailyclinicalpractice.TheemergenceanddisappearanceofNaclusters,includingthosethatcannotbegeneticallymodified."OurnextgoalistoinvestigatetheactivityofdifferentRNAsinlivingandsinglecells,whatregulatesRNAactivity,andcomparehealthyandunhealthytissueswithdiseasescausedbygeneexpressionmechanismandabnormalRNAactivity."
Originalsource
KatharinaFriedlein,YavorBozhkov,NirjharHore,AndreasMerkel,Bj?rnSommer,SebastianBrandner,MichaelBuchfelder,NicolaiE.Savaskan&IlkerY.Eyüpoglu.Anewfunctionalclassificationsystem(FGA/B)withprognosticvalueforgliomapatients.ScientificReports,July2015