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【胶质瘤病因】空气污染会不会引起胶质瘤?

【胶质瘤病因】空气污染会不会引起胶质瘤?胶质瘤资讯网提示:引起胶质瘤的病因有很多种,随着气候的不段恶化,空气的污染会不会直接影响胶质瘤呢?我们来看看详细内容。 目的 已知空...
  【胶质瘤病因】空气污染会不会引起胶质瘤?胶质瘤资讯网提示:引起胶质瘤的病因有很多种,随着气候的不段恶化,空气的污染会不会直接影响胶质瘤呢?我们来看看详细内容。
胶质瘤病因
  目的
  已知空气污染增加肺癌发生风险,目前越来越多的证据表明,空气污染也对脑部存在负面影响。我们以前曾报道一个队列研究,纳入95例患者,分析空气污染与脑肿瘤之间的关联。本研究目标是在一个大型全国性的病例对照研究中验证空气污染增加脑肿瘤发生风险。
  方法
  研究共纳入2000-2009年4183例成人脑肿瘤患者,使用样本抽样控制,匹配性别和出生年龄后得到8018例成人脑肿瘤队列研究样本。基于可信扩散模型,提取1971年以来参与者住址和平均氮氧化物浓度资料。使用logistic条件回归模型计算绝对和线性相对风险度OR和95%CI。
  结果
  研究发现,居住地氮氧化物浓度很高的参与者发生脑肿瘤的风险最高(80–99 ?g/m3,OR 1.27, 95%CI 0.82–1.96; ≥100 ?g/m3  OR 1.40, 95%CI 0.87–2.26 ,与<20 ?g/m3 NOx比较), 居住地氮氧化物浓度<80 ?g/m3的参与者发生脑肿瘤的风险没有明显增加,经线性调整后,空气氮氧化物浓度与脑肿瘤发生风险无显著性相关(OR 1.11, 95%CI 0.84–1.46 /100ug/m3 NOx )。亚组分析显示,居住地空气氮氧化物浓度≥100 ?g/m3 的参与者,发生非神经胶质瘤、神经胶质瘤的OR分别为2.30 (95%CI 1.15–4.59) 、0.89 (95%CI 0.44–1.77) 。
  结论
  这项研究结果不支持空气污染与脑肿瘤发生风险之间存在相对较强的线性相关。但是高浓度空气氮氧化物与脑肿瘤发生风险增加之间的关联值得关注,脑肿瘤形态学研究可能会产生不同结果。
  原始出处:
  Aslak Harbo Poulsen, et all. Air pollution from traffic and risk for brain tumors: a nationwide study in Denmark. Cancer Causes & Control. 18 February 2016.
  objective
  It is known that air pollution increases the risk of lung cancer. At present, more and more evidences show that air pollution also has negative effects on the brain. We previously reported a cohort study of 95 patients to analyze the association between air pollution and brain tumors. The objective of this study is to verify that air pollution increases the risk of brain tumor in a large nationwide case-control study.
  method
  A total of 4183 adult brain tumor patients were included in the study from 2000 to 2009. Using sample sampling control, 8018 adult brain tumor cohort study samples were obtained after matching gender and birth age. Based on the trusted diffusion model, the data of participants' address and average NOx concentration since 1971 were extracted. The absolute and linear relative risk or and 95% CI were calculated by logistic conditional regression model.
  Result
  The study found that the participants with high concentration of nitrogen oxides in residence had the highest risk of brain tumor (80 – 99? G / m3, or 1.27, 95% CI 0.82 – 1.96; ≥ 100? G / m3, or 1.40, 95% CI 0.87 – 2.26, compared with < 20? G / M3 NOx). The participants with low concentration of nitrogen oxides in residence had no significant increase in the risk of brain tumor. After linear adjustment, the concentration of nitrogen oxides in air had no significant increase There was no significant correlation with the risk of brain tumor (or 1.11, 95% CI 0.84 – 1.46 / 100ug / m3 NOx). Subgroup analysis showed that the or of non gliomas and gliomas were 2.30 (95% CI 1.15-4.59) and 0.89 (95% CI 0.44-1.77), respectively.
  conclusion
  The results of this study do not support a relatively strong linear correlation between air pollution and the risk of brain cancer. However, the relationship between high concentration of air nitrogen oxides and the increased risk of brain tumor is worthy of attention. The morphological study of brain tumor may produce different results.
  Original source:
  Aslak Harbo Poulsen, et all. Air pollution from traffic and risk for brain tumors: a nationwide study in Denmark. Cancer Causes & Control. 18 February 2016.

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